Nowadays, with the increasing consumption of the traditional, non-renewable fossil resources, we are in urgent need to build highly efficient matter catalytic conversion processes for sustainable chemistry, green chemistry and energy chemistry. Supramolecular catalysis, as interdisciplinary integration of supramolecular chemistry and catalysis, has enabled tremendous advantages and paved a way for boosting highly efficient and selective transformations. With enzyme-mimetic pocket and specific recognition ability, macrocyclic compounds have shown great potential in the development of high-efficiency supramolecular catalytic systems. At present, the binding and activation is mainly driven by limited cation-relevant interactions or hydrophobic effects. Inspired by anionic supramolecular chemistry and considering that anions, as a widely existing species in nature, participate in many chemical transformation processes, we propose to establish a different, anion-recognition directed strategy. Taking the advantages of the rich variety, geometry and interaction sites of anions, we aim to manipulate sophisticated noncovalent networks for driving efficient and selective catalysis on challenging chemical transformations.